A new class of drug (Neprilysin inhibitor ) when combined with angiotensin receptor blocker , has been shown to be better than Enalapril. Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure — NEJM.
What is sudden cardiac death (SCD) ? Sudden cardiac death is defined as natural death from cardiac causes, heralded by abrupt loss of consciousness within 1 hour of the onset of an acute change in cardiovascular status. Related terms are sudden cardiac arrest and cardiovascular collapse. Sudden cardiac arrest means abrupt cessation of cardiac mechanical […]
V- Wave Novel Catheter-Implanted Device Benefits Patients with Left Heart Failure
Implantable cardioverter defibrillator (ICD) – the others New ACC/AHA/HRS Expert consensus document for implantable cardioverter defibrillator (ICD) implantation in patients who are excluded or not well represented in clinical trials. A guideline has been published for ICD implantation. This new document is a good attempt at helping cardiologists in deciding about ICD. There are some […]
Percutaneous ventricular restoration therapy This is a new form of device therapy for heart failure. The device used is Parachute implant® (http://www.cardiokinetix.com/). Parachute implant is an umbrella shaped device that is inserted into the left ventricle. Pathophysiological basis of use: – In post MI patients there is progressive LV remodelling (progressive dilatation of the […]
FDA Approves Medtronic CRT Devices for Mild HF With AV Block. This approval is based on the BLOCK-HF trial. The approval expands the labeling on the defibrillating and pacing-only cardiac resynchronization therapy devices (CRT-D and CRT-P, respectively), which until now had been approved only for heart-failure patients with LVEF <35% and prolonged QRS intervals. The BLOCK-HF indications […]
Characterization of a Novel Symptom of Advanced Heart Failure: Bendopnea JCHF. 2014;2(1):24-31. doi:10.1016/j.jchf.2013.07.009 Objectives: This study sought to examine the frequency and hemodynamic correlates of shortness of breath when bending forward, a symptom that has been named by the newly coined term “bendopnea.” Background: Many heart failure patients describe bendopnea such as when putting on their shoes. This […]
Heart failure is associated with activation of inflammatory cascades. this trial examines the effects of usig colchicine in Hf. American College of Cardiology Foundation | JACC: Heart Failure | Anti-Inflammatory Treatment With Colchicine in Stable Chronic Heart FailureA Prospective, Randomized Study.
Details of topcat trial Pfeffer_TOPCAT
TOPCAT trial shows no benefit of spironolactone in terms of death, hospitalization, aborted SCD in heart failure with preserved ejection fraction. Spironolactone for Heart Failure with Preserved Ejection Fraction — NEJM.