PARADIGM-HF Trial

A new class of drug (Neprilysin inhibitor ) when combined with angiotensin receptor blocker , has been shown to be better than Enalapril. Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure — NEJM.

Sudden cardiac death

What is sudden cardiac death (SCD) ? Sudden cardiac death is defined as natural death from cardiac causes, heralded by abrupt loss of consciousness within 1 hour of the onset of an acute change in cardiovascular status. Related terms are sudden cardiac arrest and cardiovascular collapse. Sudden cardiac arrest means abrupt cessation of cardiac mechanical […]

Implantable cardioverter defibrillator (ICD) – the others

Implantable cardioverter defibrillator (ICD) – the others New ACC/AHA/HRS Expert consensus document for implantable cardioverter defibrillator (ICD) implantation in patients who are excluded or not well represented in clinical trials. A guideline has been published for ICD implantation. This new document is a good attempt at helping cardiologists in deciding about ICD. There are some […]

Percutaneous ventricular restoration therapy

Percutaneous ventricular restoration therapy This is a new form of device therapy for heart failure. The device used is Parachute implant® (http://www.cardiokinetix.com/). Parachute implant is an umbrella shaped device that is inserted into the left ventricle. Pathophysiological basis of use: –          In post MI patients there is progressive LV remodelling (progressive dilatation of the   […]

CRT – the expanded indications

FDA Approves Medtronic CRT Devices for Mild HF With AV Block. This approval is based on the  BLOCK-HF trial. The approval expands the labeling on the defibrillating and pacing-only cardiac resynchronization therapy devices (CRT-D and CRT-P, respectively), which until now had been approved only for heart-failure patients with LVEF <35% and prolonged QRS intervals. The BLOCK-HF indications […]

The unheard-of symptom – Bendopnea

Characterization of a Novel Symptom of Advanced Heart Failure: Bendopnea JCHF. 2014;2(1):24-31. doi:10.1016/j.jchf.2013.07.009 Objectives:  This study sought to examine the frequency and hemodynamic correlates of shortness of breath when bending forward, a symptom that has been named by the newly coined term “bendopnea.” Background:  Many heart failure patients describe bendopnea such as when putting on their shoes. This […]

Colchicine in Stable Chronic Heart Failure

Heart failure is associated with activation of inflammatory cascades. this trial examines the effects of usig colchicine in Hf. American College of Cardiology Foundation | JACC: Heart Failure | Anti-Inflammatory Treatment With Colchicine in Stable Chronic Heart FailureA Prospective, Randomized Study.

TOPCAT trial

TOPCAT trial shows no benefit of spironolactone in terms of death, hospitalization, aborted SCD in heart failure with preserved ejection fraction. Spironolactone for Heart Failure with Preserved Ejection Fraction — NEJM.

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