Clonidine in patients undergoing noncardiac surgery

Marked activation of the sympathetic nervous system occurs during and after noncardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may prevent perioperative myocardial infarction and death without inducing hemodynamic instability. POISE-2 study shows no benefit and increased risk http://www.nejm.org/doi/full/10.1056/NEJMoa1401106?query=cardiology

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