Various reports have been published about the association of anti- depressant use in first trimester of pregnancy and resultant cardiac malformations.
Depression is seen in 10-15% of pregnant females. Reports have suggested that paroxetin is associated with right ventricular outflow tract obstruction and sertaline to be associated with ventricular septal defects.
This present large study shows that there is no increase in cardiac malformation with antidepressant use.
N Engl J Med 2014;370:2397-407.