Marked activation of the sympathetic nervous system occurs during and after noncardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may prevent perioperative myocardial infarction and death without inducing hemodynamic instability.
POISE-2 study shows no benefit and increased risk
Myocardial infarction is the most common major vascular complication that occurs after noncardiac surgery. this Canadian study examines the issue of prophylactic aspirin in patients undergoing non-cardiac surgery. Read more @ POISE-2 study