High versus Low Blood-Pressure Target in Patients with Septic Shock — NEJM.
Marked activation of the sympathetic nervous system occurs during and after noncardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may prevent perioperative myocardial infarction and death without inducing hemodynamic instability. POISE-2 study shows no benefit and increased risk http://www.nejm.org/doi/full/10.1056/NEJMoa1401106?query=cardiology
Myocardial infarction is the most common major vascular complication that occurs after noncardiac surgery. this Canadian study examines the issue of prophylactic aspirin in patients undergoing non-cardiac surgery. Read more @ POISE-2 study http://www.nejm.org/doi/full/10.1056/NEJMoa1401105?query=cardiology