Antiplatelet Therapy for Stable CAD in AF Patients Taking an Oral Anticoagulant

Background—The optimal long-term antithrombotic treatment of patients with coexisting atrial fibrillation and stable coronary artery disease is unresolved, and commonly, a single antiplatelet agent is added to oral anticoagulation. The study investigated the effectiveness and safety of adding antiplatelet therapy to vitamin K antagonist (VKA) in atrial fibrillation patients with stable coronary artery disease. Methods […]

MI rates with Ticagrelor (from PLATO)

This article in JACC examines the rates of MI in patients with ACS treated with ticagrelor vs clopidogrel. The rates of overall MI at 12 months: 1. Ticagrelor- 5.8% 2. Clopidogrel – 6.9% 3. Nonprocedural MI (HR: 0.86; 95% CI: 0.74 to 1.01) and MI related to percutaneous      coronary intervention or stent thrombosis tended […]

Colchicine in Stable Chronic Heart Failure

Heart failure is associated with activation of inflammatory cascades. this trial examines the effects of usig colchicine in Hf. American College of Cardiology Foundation | JACC: Heart Failure | Anti-Inflammatory Treatment With Colchicine in Stable Chronic Heart FailureA Prospective, Randomized Study.

Natural history of pediatric idiopathic DCM

Natural history studies of pediatric idiopathic dcm are scarce. previous studies have demonstrated heterogenous figures of actuarial survival at 1 year of 63-90%, and at 5 years of 20-80%. this study add to our knowledge of natural history and LV function recovery. American College of Cardiology Foundation | Journal of the American College of Cardiology […]

REOPEN-AMI Trial

high-dose intracoronary adenosine after thrombus aspiration improves microvascular dysfunction, LV remodelling. American College of Cardiology Foundation | Journal of the American College of Cardiology | Left Ventricular Remodeling and 1-Year Clinical Follow-Up of the REOPEN-AMI Trial.

TOPCAT trial

TOPCAT trial shows no benefit of spironolactone in terms of death, hospitalization, aborted SCD in heart failure with preserved ejection fraction. Spironolactone for Heart Failure with Preserved Ejection Fraction — NEJM.

Application of New Cholesterol Guidelines to a Population-Based Sample — NEJM

The new ACC–AHA guidelines for the management of cholesterol would increase the number of adults who would be eligible for statin therapy by a large number, with the increase seen mostly among older adults without cardiovascular disease Application of New Cholesterol Guidelines to a Population-Based Sample — NEJM.

A Controlled Trial of Renal Denervation for Resistant Hypertension — NEJM

Renal denervation in resistant hypertension doesn’t show significant BP reduction. A Controlled Trial of Renal Denervation for Resistant Hypertension — NEJM.

Transcatheter Aortic-Valve Replacement with a Self-Expanding Prosthesis — NEJM

improved survival with TAVI as compared to surgery in high surgical risk patients. Transcatheter Aortic-Valve Replacement with a Self-Expanding Prosthesis — NEJM.  

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