Bionic Pancreas in Type 1 Diabetes

The study concluded as compared with an insulin pump, a wearable, automated, bihormonal, bionic pancreas improved mean glycemic levels, with less frequent hypoglycemic episodes, among both adults and adolescents with type 1 diabetes mellitus. Read more at: Outpatient Glycemic Control with a Bionic Pancreas in Type 1 Diabetes — NEJM.

APPOSITION IV : Trial

STENTYS SELF APPOSITION SES: It is a self-expandable sirolimus-eluting coronary stent system, similar in concept to other self-expanding systems. Watch the video: Stentys self-apposition SES APPOSITION IV trial: –Patients – 152 patients presenting with STEMI. –Design: Patients were randomized to Stentys self-apposing SES (Stentys, Paris, France; n = 90)   vs Resolute zotarolimus-eluting stent (ZES; Medtronic, […]

Vorapaxar (Zontivity) approved

CardioSource – FDA Approves Vorapaxar to Reduce Heart Attack and Stroke Risks in HighRisk Patients. The U.S. Food and Drug Administration (FDA) has approved vorapaxar (Zontivity) to reduce the risk for MI, stroke, cardiovascular-related death and coronary revascularization among patients who have previously experienced MI or peripheral artery disease. Vorapaxar is the first in a […]

Genetic mutation in Metabolic Syndrome

A Form of the Metabolic Syndrome Associated with Mutations in DYRK1B — NEJM.   A founder mutation was identified in DYRK1B, substituting cysteine for arginine at position 102 in the highly conserved kinase-like domain. The mutation precisely cosegregated with the clinical syndrome. Functional characterization of the disease gene revealed that nonmutant protein encoded by DYRK1B inhibits […]

Renal artery denervation in post-stenting patients

RENAL ARTERY DENERVATION FOR HYPERTENSION REFRACTORY TO STENTING A new study published in Journal of endovascular therapy (2014;21:181–190) has evaluated the efficacy of renal denervation therapy for hypertension refractory to renal artery stenting. The study included ten patients (6 women; mean age 70.0±5.1 years) with an office systolic blood pressure >160 mmHg despite taking ≥3 […]

EARLY STENT THROMBOSIS

EARLY STENT THROMBOSIS- AN AUTOPSY STUDY OF LESION CHARACTERISTICS According to a study published online ahead of print in the Journal of American college of cardiology ,patients with acute coronary syndromes (ACS) undergoing percutaneous coronary intervention (PCI) face increased risk of early stent thrombosis in the presence of high thrombus burden with certain pathological traits […]

CRT – the expanded indications

FDA Approves Medtronic CRT Devices for Mild HF With AV Block. This approval is based on the  BLOCK-HF trial. The approval expands the labeling on the defibrillating and pacing-only cardiac resynchronization therapy devices (CRT-D and CRT-P, respectively), which until now had been approved only for heart-failure patients with LVEF <35% and prolonged QRS intervals. The BLOCK-HF indications […]

The unheard-of symptom – Bendopnea

Characterization of a Novel Symptom of Advanced Heart Failure: Bendopnea JCHF. 2014;2(1):24-31. doi:10.1016/j.jchf.2013.07.009 Objectives:  This study sought to examine the frequency and hemodynamic correlates of shortness of breath when bending forward, a symptom that has been named by the newly coined term “bendopnea.” Background:  Many heart failure patients describe bendopnea such as when putting on their shoes. This […]

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