Percutaneous ventricular restoration therapy

Percutaneous ventricular restoration therapy This is a new form of device therapy for heart failure. The device used is Parachute implant® (http://www.cardiokinetix.com/). Parachute implant is an umbrella shaped device that is inserted into the left ventricle. Pathophysiological basis of use: –          In post MI patients there is progressive LV remodelling (progressive dilatation of the   […]

APPOSITION IV : Trial

STENTYS SELF APPOSITION SES: It is a self-expandable sirolimus-eluting coronary stent system, similar in concept to other self-expanding systems. Watch the video: Stentys self-apposition SES APPOSITION IV trial: –Patients – 152 patients presenting with STEMI. –Design: Patients were randomized to Stentys self-apposing SES (Stentys, Paris, France; n = 90)   vs Resolute zotarolimus-eluting stent (ZES; Medtronic, […]

Coronary artery disease

Coronary artery disease The heart like any other organ in the body needs constant supply of blood to survive. Blood reaches different parts of the heart through the coronary arteries.  Coronary arteries are of vital importance for the sustenance of life. The different  normal functions of the coronary arteries include: 1. Carrying blood to different […]

Vorapaxar (Zontivity) approved

CardioSource – FDA Approves Vorapaxar to Reduce Heart Attack and Stroke Risks in HighRisk Patients. The U.S. Food and Drug Administration (FDA) has approved vorapaxar (Zontivity) to reduce the risk for MI, stroke, cardiovascular-related death and coronary revascularization among patients who have previously experienced MI or peripheral artery disease. Vorapaxar is the first in a […]

Genetic mutation in Metabolic Syndrome

A Form of the Metabolic Syndrome Associated with Mutations in DYRK1B — NEJM.   A founder mutation was identified in DYRK1B, substituting cysteine for arginine at position 102 in the highly conserved kinase-like domain. The mutation precisely cosegregated with the clinical syndrome. Functional characterization of the disease gene revealed that nonmutant protein encoded by DYRK1B inhibits […]

APPROACH TO SYNCOPE

APPROACH TO SYNCOPE History taking in cardiology cont. Syncope has been defined by the European society of cardiology as “A transient loss of consciousness due to transient global cerebral hypoperfusion characterized by rapid onset, short duration, and spontaneous recovery.” Syncope is a common problem, it causes significant agony and apprehension and may result in serious […]

Renal artery denervation in post-stenting patients

RENAL ARTERY DENERVATION FOR HYPERTENSION REFRACTORY TO STENTING A new study published in Journal of endovascular therapy (2014;21:181–190) has evaluated the efficacy of renal denervation therapy for hypertension refractory to renal artery stenting. The study included ten patients (6 women; mean age 70.0±5.1 years) with an office systolic blood pressure >160 mmHg despite taking ≥3 […]

EARLY STENT THROMBOSIS

EARLY STENT THROMBOSIS- AN AUTOPSY STUDY OF LESION CHARACTERISTICS According to a study published online ahead of print in the Journal of American college of cardiology ,patients with acute coronary syndromes (ACS) undergoing percutaneous coronary intervention (PCI) face increased risk of early stent thrombosis in the presence of high thrombus burden with certain pathological traits […]

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