Details of topcat trial Pfeffer_TOPCAT
TOPCAT trial shows no benefit of spironolactone in terms of death, hospitalization, aborted SCD in heart failure with preserved ejection fraction. Spironolactone for Heart Failure with Preserved Ejection Fraction — NEJM.
The new ACC–AHA guidelines for the management of cholesterol would increase the number of adults who would be eligible for statin therapy by a large number, with the increase seen mostly among older adults without cardiovascular disease Application of New Cholesterol Guidelines to a Population-Based Sample — NEJM.
Renal denervation in resistant hypertension doesn’t show significant BP reduction. A Controlled Trial of Renal Denervation for Resistant Hypertension — NEJM.
improved survival with TAVI as compared to surgery in high surgical risk patients. Transcatheter Aortic-Valve Replacement with a Self-Expanding Prosthesis — NEJM.
High versus Low Blood-Pressure Target in Patients with Septic Shock — NEJM.
Marked activation of the sympathetic nervous system occurs during and after noncardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may prevent perioperative myocardial infarction and death without inducing hemodynamic instability. POISE-2 study shows no benefit and increased risk http://www.nejm.org/doi/full/10.1056/NEJMoa1401106?query=cardiology
Myocardial infarction is the most common major vascular complication that occurs after noncardiac surgery. this Canadian study examines the issue of prophylactic aspirin in patients undergoing non-cardiac surgery. Read more @ POISE-2 study http://www.nejm.org/doi/full/10.1056/NEJMoa1401105?query=cardiology
Heart attack is a dreaded event for anyone. Ever thought how you can know that you are having a heart attack. The fact is an early recognition of attack results in early treatment. This in turn leads to less suffering and risk of death. What are the symptoms? Heart attack can present in different ways. […]