TOPCAT trial

TOPCAT trial shows no benefit of spironolactone in terms of death, hospitalization, aborted SCD in heart failure with preserved ejection fraction. Spironolactone for Heart Failure with Preserved Ejection Fraction — NEJM.

Application of New Cholesterol Guidelines to a Population-Based Sample — NEJM

The new ACC–AHA guidelines for the management of cholesterol would increase the number of adults who would be eligible for statin therapy by a large number, with the increase seen mostly among older adults without cardiovascular disease Application of New Cholesterol Guidelines to a Population-Based Sample — NEJM.

A Controlled Trial of Renal Denervation for Resistant Hypertension — NEJM

Renal denervation in resistant hypertension doesn’t show significant BP reduction. A Controlled Trial of Renal Denervation for Resistant Hypertension — NEJM.

Transcatheter Aortic-Valve Replacement with a Self-Expanding Prosthesis — NEJM

improved survival with TAVI as compared to surgery in high surgical risk patients. Transcatheter Aortic-Valve Replacement with a Self-Expanding Prosthesis — NEJM.  

Clonidine in patients undergoing noncardiac surgery

Marked activation of the sympathetic nervous system occurs during and after noncardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may prevent perioperative myocardial infarction and death without inducing hemodynamic instability. POISE-2 study shows no benefit and increased risk http://www.nejm.org/doi/full/10.1056/NEJMoa1401106?query=cardiology

Aspirin for prevention in patients undergoing noncardiac surgery

Myocardial infarction is the most common major vascular complication that occurs after noncardiac surgery. this Canadian study examines the issue of prophylactic  aspirin in patients undergoing non-cardiac surgery. Read more @ POISE-2 study http://www.nejm.org/doi/full/10.1056/NEJMoa1401105?query=cardiology

Symptoms of heart attack

Heart attack is a dreaded event for anyone. Ever thought how you can know that you are having a heart attack. The fact is an early recognition of attack results in early treatment. This in turn leads to less suffering and risk of death. What are the symptoms? Heart attack can present in different ways. […]

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